Akr7a2 Gene Summary [Rat]
Enables aldose reductase (NADPH) activity. Predicted to be involved in daunorubicin metabolic process and doxorubicin metabolic process. Located in nuclear envelope. Orthologous to human AKR7A2 (aldo-keto reductase family 7 member A2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akr7a2 |
| Official Name | aldo-keto reductase family 7, member A2 [Source:RGD Symbol;Acc:620311] |
| Ensembl ID | ENSRNOG00000017780 |
| Bio databases IDs | |
| Aliases | aldo-keto reductase family 7, member A2 |
| Synonyms | 0610025K21Rik, 2-Cba Reductase, AFAR, AFAR1, AFB1-AR1, Aiar, AKR7, Akr7a5, aldo-keto reductase family 7 member A2, aldo-keto reductase family 7, member A2, aldo-keto reductase family 7, member A5, SSA Reductase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Akr7a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- electron carrier
- Aldo-keto reductase (AKR) superfamily
- aldo-keto reductase
- phenanthrene-9,10-epoxide hydrolase
- Aldo/keto reductase family
- enzyme
- protein binding
- identical protein binding
- aldehyde reductase
Pathways
Biological processes and signaling networks where the Akr7a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rotator cuff injury
- breast cancer
regulates
- doxorubicin
- carbohydrate
- aldehyde
- 4-hydroxybutanoic acid
- daunorubicin
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Akr7a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- cellular aldehyde metabolic process
- lipid metabolic process
- daunorubicin metabolic process
- doxorubicin metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- electron carrier activity
- alditol:NADP+ 1-oxidoreductase activity
- aldo-keto reductase (NADP) activity
- phenanthrene-9,10-epoxide hydrolase activity