Nudt8 Gene Summary [Rat]

Predicted to enable magnesium ion binding activity and manganese ion binding activity. Predicted to be involved in purine nucleoside bisphosphate catabolic process. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
Nudt8
Official Name
nudix hydrolase 8 [Source:RGD Symbol;Acc:1309040]
Ensembl ID
ENSRNOG00000017955
Bio databases IDs NCBI: 361692 Ensembl: ENSRNOG00000017955
Aliases nudix hydrolase 8
Synonyms 2310039H17RIK, LOC683919, nudix hydrolase 8
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nudt8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • NUDIX domain
  • pyrophosphatase
  • enzyme
  • manganese ion binding
  • magnesium ion binding
  • NUDIX hydrolase superfamily

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
regulates
  • propionyl-coenzyme A
  • coenzyme A
  • succinyl-coenzyme A
  • acetyl-coenzyme A
  • butyryl-coenzyme A
role in cell
  • fludarabine resistance

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Mitochondria
  • mitochondrial matrix

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Nudt8 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • malonyl-CoA catabolic process
  • butyryl-CoA catabolic process
  • medium-chain fatty-acyl-CoA catabolic process
  • coenzyme A catabolic process
  • acetyl-CoA catabolic process

Cellular Component

Where in the cell the gene product is active
  • mitochondrion

Molecular Function

What the gene product does at the molecular level
  • magnesium ion binding
  • CoA pyrophosphatase activity
  • manganese ion binding

Gene-Specific Assays for Results You Can Trust

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