Nudt8 Gene Summary [Mouse]
Enables coenzyme A diphosphatase activity; magnesium ion binding activity; and manganese ion binding activity. Involved in nucleoside phosphate catabolic process. Located in mitochondrion. Orthologous to human NUDT8 (nudix hydrolase 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nudt8 |
| Official Name | nudix (nucleoside diphosphate linked moiety X)-type motif 8 [Source:MGI Symbol;Acc:MGI:1913637] |
| Ensembl ID | ENSMUSG00000110949 |
| Bio databases IDs | |
| Aliases | nudix (nucleoside diphosphate linked moiety X)-type motif 8 |
| Synonyms | 2310039H17RIK, LOC683919, nudix hydrolase 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nudt8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NUDIX domain
- pyrophosphatase
- enzyme
- manganese ion binding
- magnesium ion binding
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nudt8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- malonyl-CoA catabolic process
- butyryl-CoA catabolic process
- medium-chain fatty-acyl-CoA catabolic process
- coenzyme A catabolic process
- acetyl-CoA catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- CoA pyrophosphatase activity
- manganese ion binding