Hmox2 Gene Summary [Rat]
Enables heme oxygenase (decyclizing) activity. Involved in response to oxidative stress. Predicted to be located in plasma membrane. Orthologous to human HMOX2 (heme oxygenase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmox2 |
| Official Name | heme oxygenase 2 [Source:RGD Symbol;Acc:67402] |
| Ensembl ID | ENSRNOG00000003773 |
| Bio databases IDs | |
| Aliases | heme oxygenase 2 |
| Synonyms | heme oxygenase 2, HO-2, LOC100361038 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hmox2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- heme oxygenase
- heme oxygenase (decyclizing)
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Hmox2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- conduction delay
- non-small cell lung carcinoma
- Parkinson disease
- touch abnormality
- hypoxia
- progressive dilated cardiomyopathy
role in cell
- cell death
- activation
- apoptosis
- activation in
- survival
- upregulation in
- depolarization
- response by
- downregulation in
- depolarization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- pH resistant lipid raft fraction
- Plasma Membrane
- specific granule membrane
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- microsome
- cytoplasmic droplets
- residual bodies
- microsomal membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hmox2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- response to hypoxia
- heme catabolic process
- heme oxidation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- heme oxygenase (decyclizing) activity
- heme binding