Duoxa1 Gene Summary [Rat]
Predicted to enable enzyme binding activity. Predicted to be involved in positive regulation of hydrogen peroxide biosynthetic process and protein localization. Predicted to act upstream of or within several processes, including hydrogen peroxide metabolic process; positive regulation of reactive oxygen species metabolic process; and regulation of thyroid hormone generation. Predicted to be located in cell leading edge; endoplasmic reticulum; and plasma membrane. Predicted to be active in membrane. Orthologous to human DUOXA1 (dual oxidase maturation factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Duoxa1 |
| Official Name | dual oxidase maturation factor 1 [Source:RGD Symbol;Acc:1306601] |
| Ensembl ID | ENSRNOG00000018005 |
| Bio databases IDs | |
| Aliases | dual oxidase maturation factor 1 |
| Synonyms | BC019755, dual oxidase maturation factor 1, FLJ32334, mol, NIP, Nip1, NLP, NUMBIP, RGD1306601 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Duoxa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual oxidase maturation factor
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital hypothyroidism
- epithelial thyroid cancer
- endocarditis
- androgenic alopecia
- papillary thyroid carcinoma
- papillary thyroid cancer
- thyroid dyshormonogenesis 5
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- iodide organification defect
role in cell
- expression in
- production in
- differentiation
- fragmentation
- processing in
- replicative senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Endoplasmic Reticulum
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Duoxa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of hydrogen peroxide biosynthetic process
- regulation of thyroid hormone generation
- protein transport
- protein localization
- positive regulation of neuron differentiation
- regulation of inflammatory response
- hydrogen peroxide metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding