Dctn2 Gene Summary [Rat]
Predicted to enable identical protein binding activity; protein kinase binding activity; and spectrin binding activity. Predicted to be involved in mitotic metaphase chromosome alignment and mitotic spindle organization. Predicted to act upstream of or within melanosome transport and protein localization to centrosome. Located in centrosome and kinetochore. Part of dynactin complex. Biomarker of synucleinopathy. Orthologous to human DCTN2 (dynactin subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dctn2 |
| Official Name | dynactin subunit 2 [Source:RGD Symbol;Acc:1303182] |
| Ensembl ID | ENSRNOG00000025481 |
| Bio databases IDs | |
| Aliases | dynactin subunit 2 |
| Synonyms | 2310042E05RIK, C130077D06RIK, DCTN-50, dynactin 2, dynactin subunit 2, DYNAMITIN, GMP23-48K, HEL-S-77, p50, p50 DYNAMITIN, RBP50 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dctn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- macmarcks binding domain
- spectrin binding
- protein binding
- Dynamitin
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- pathological denervation
- neurodegenerative disorder
- neurodegeneration
role in cell
- cell death
- activation in
- quantity
- production in
- migration
- degradation in
- assembly
- binding
- organization
- translocation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- perinuclear region
- Nucleus
- Plasma Membrane
- vesicles
- centrosome
- cytosol
- growth cone
- plus end of microtubule
- kinetochores
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dctn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic spindle organization
- mitotic metaphase plate congression
- protein localization to centrosome
- melanosome transport
Cellular Component
Where in the cell the gene product is active
- growth cone
- centrosome
- extracellular vesicular exosome
- cytoplasm
- dynactin complex
- membrane
- dynein complex
- vesicle
- cytosol
- kinetochore
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein binding
- spectrin binding