Slc22a8 Gene Summary [Rat]
Enables organic anion transmembrane transporter activity; protein kinase C binding activity; and quaternary ammonium group transmembrane transporter activity. Involved in glutathione transport and quaternary ammonium group transport. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human SLC22A8 (solute carrier family 22 member 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc22a8 |
| Official Name | solute carrier family 22 member 8 [Source:RGD Symbol;Acc:632286] |
| Ensembl ID | ENSRNOG00000018086 |
| Bio databases IDs | |
| Aliases | solute carrier family 22 member 8 |
| Synonyms | OAT3, OCT3, Roct, solute carrier family 22 member 8, solute carrier family 22 (organic anion transporter), member 8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc22a8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- benzoate transport
- protein kinase C binding
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- Multidrug resistance protein
- phosphate:H+ symporter
- organic anion transporter
- prostaglandin transporter
- organic cation transporter
- Sugar (and other) transporter
- xenobiotic transporter
- antiporter
- inorganic anion exchanger
- cation transport protein
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- complicated urinary tract infection
- intra-abdominal infection
- urinary tract infection
- obesity
- side effect
- epilepsy
- HIV infection
- overall survival
- gout
- disease-free survival
regulates
- glutathione
- estrone sulfate
- indican
- sitagliptin
- cimetidine
- SLC22A8
- 4-carboxyfluorescein
- bestatin
- taurocholic acid
- quaternary ammonium compound
role in cell
- cell viability
- uptake in
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical membrane
- basolateral membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc22a8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inorganic anion transport
- ion transport
- transmembrane transport
- xenobiotic transport
- response to toxin
- prostaglandin transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- xenobiotic transporter activity
- prostaglandin transmembrane transporter activity
- inorganic anion exchanger activity
- organic anion transmembrane transporter activity