SLC22A8 Gene Summary [Human]
This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]
Details
| Type | Retained Intron |
| Official Symbol | SLC22A8 |
| Official Name | solute carrier family 22 member 8 [Source:HGNC Symbol;Acc:HGNC:10972] |
| Ensembl ID | ENSG00000149452 |
| Bio databases IDs | |
| Aliases | solute carrier family 22 member 8 |
| Synonyms | OAT3, OCT3, Roct, solute carrier family 22 member 8, solute carrier family 22 (organic anion transporter), member 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC22A8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- benzoate transport
- protein kinase C binding
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- Multidrug resistance protein
- phosphate:H+ symporter
- organic anion transporter
- prostaglandin transporter
- organic cation transporter
- Sugar (and other) transporter
- xenobiotic transporter
- antiporter
- inorganic anion exchanger
- cation transport protein
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- complicated urinary tract infection
- intra-abdominal infection
- urinary tract infection
- obesity
- side effect
- epilepsy
- HIV infection
- overall survival
- gout
- disease-free survival
regulates
- glutathione
- estrone sulfate
- indican
- sitagliptin
- cimetidine
- SLC22A8
- 4-carboxyfluorescein
- bestatin
- taurocholic acid
- quaternary ammonium compound
role in cell
- cell viability
- uptake in
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical membrane
- basolateral membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC22A8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inorganic anion transport
- ion transport
- transmembrane transport
- xenobiotic transport
- response to toxin
- prostaglandin transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- xenobiotic transporter activity
- prostaglandin transmembrane transporter activity
- inorganic anion exchanger activity
- organic anion transmembrane transporter activity