Thtpa Gene Summary [Rat]
Predicted to enable magnesium ion binding activity and thiamine triphosphate phosphatase activity. Predicted to be involved in dephosphorylation and thiamine diphosphate biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human THTPA (thiamine triphosphatase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Thtpa |
| Official Name | thiamine triphosphatase [Source:RGD Symbol;Acc:727917] |
| Ensembl ID | ENSRNOG00000018105 |
| Bio databases IDs | |
| Aliases | thiamine triphosphatase |
| Synonyms | MGC2652, thiamine triphosphatase, THTP, THTPASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Thtpa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thiamine-triphosphatase
- phosphatase
- CYTH-like phosphatase
- thiamin-triphosphatase
- hydrolase
- protein binding
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Thtpa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- thiamine metabolic process
- dephosphorylation
- thiamine diphosphate biosynthetic process
- thiamine diphosphate metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- protein binding
- thiamin-triphosphatase activity
- hydrolase activity