Thtpa Gene Summary [Mouse]
This gene encodes a cytosolic enzyme that catalyzes the conversion of thiamine triphosphate to thiamine diphosphate. The encoded protein requires divalent cations for enzymatic activity. The gene product is believed to play a role in regulation of thiamine triphosphate intracellular concentration, and it may be a messenger in cell signaling in response to cellular stress. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | Thtpa |
| Official Name | thiamine triphosphatase [Source:MGI Symbol;Acc:MGI:2446078] |
| Ensembl ID | ENSMUSG00000045691 |
| Bio databases IDs | |
| Aliases | thiamine triphosphatase |
| Synonyms | MGC2652, thiamine triphosphatase, THTP, THTPASE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Thtpa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thiamine-triphosphatase
- phosphatase
- CYTH-like phosphatase
- thiamin-triphosphatase
- hydrolase
- protein binding
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Thtpa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- thiamine metabolic process
- dephosphorylation
- thiamine diphosphate biosynthetic process
- thiamine diphosphate metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- protein binding
- thiamin-triphosphatase activity
- hydrolase activity