Clpx Gene Summary [Rat]
Predicted to enable ATP binding activity; ATP hydrolysis activity; and peptidase activator activity. Predicted to contribute to ATP-dependent peptidase activity. Predicted to be involved in ATP metabolic process and proteolysis involved in protein catabolic process. Predicted to be located in cytosol; mitochondrial nucleoid; and nucleoplasm. Predicted to be part of mitochondrial endopeptidase Clp complex. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in erythropoietic protoporphyria. Orthologous to human CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit X). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clpx |
| Official Name | caseinolytic mitochondrial matrix peptidase chaperone subunit [Source:RGD Symbol;Acc:1304883] |
| Ensembl ID | ENSRNOG00000030225 |
| Bio databases IDs | |
| Aliases | caseinolytic mitochondrial matrix peptidase chaperone subunit |
| Synonyms | caseinolytic mitochondrial matrix peptidase chaperone subunit, caseinolytic mitochondrial matrix peptidase chaperone subunit X, E330029I21, EPP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Clpx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP binding
- endopeptidase Clp ATP-binding regulatory subunit (clpX)
- enzyme
- protein binding
- ATP-dependent peptidase
- protease activator
- AAA domain (Cdc48 subfamily)
- ATPase
- C-terminal, D2-small domain, of ClpB protein
- ATP-dependent protease HslVU, ATPase subunit
- AAA domain (dynein-related subfamily)
- Zn-ribbon
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- erythropoietic protoporphyria type 2
- bipolar disorder
role in cell
- degradation in
- expression in
- production in
- binding in
- phosphorylation in
- josamycin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial nucleoids
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Clpx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- ATP metabolic process
- protein folding
- proteolysis involved in cellular protein catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
- endopeptidase Clp complex
- mitochondrial endopeptidase Clp complex
- mitochondrial inner membrane
- mitochondrial nucleoid
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- zinc ion binding
- peptidase activator activity
- protein binding
- protein dimerization activity
- unfolded protein binding
- ATP-dependent peptidase activity