Prpf18 Gene Summary [Rat]
Involved in negative regulation of protein metabolic process. Predicted to be located in nuclear speck. Predicted to be part of U2-type post-spliceosomal complex; U4/U6 x U5 tri-snRNP complex; and U5 snRNP. Orthologous to human PRPF18 (pre-mRNA processing factor 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prpf18 |
| Official Name | pre-mRNA processing factor 18 [Source:RGD Symbol;Acc:708550] |
| Ensembl ID | ENSRNOG00000018396 |
| Bio databases IDs | |
| Aliases | pre-mRNA processing factor 18 |
| Synonyms | 2810441A10Rik, hPrp18, KCRF, LOC101928497, LOC101928524, Pprf18, pre-mRNA processing factor 18, PRP18 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prpf18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pre-mRNA processing factor 4 (PRP4) like
- protein binding
- Prp18 domain
- transporter
- Splicing Factor Motif, present in Prp18 and Pr04
Pathways
Biological processes and signaling networks where the Prpf18 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- spliceosomes
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prpf18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- generation of catalytic spliceosome for second transesterification step
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- U2-type post-spliceosomal complex
- nucleus
- nuclear speck
- U4/U6 x U5 tri-snRNP complex
- U5 snRNP
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding