Ascc2 Gene Summary [Rat]
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and ubiquitin binding activity. Predicted to be involved in regulation of DNA-templated transcription; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of DNA repair complex and RQC-trigger complex. Predicted to be active in cytosolic ribosome. Orthologous to human ASCC2 (activating signal cointegrator 1 complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ascc2 |
| Official Name | activating signal cointegrator 1 complex subunit 2 [Source:RGD Symbol;Acc:1561422] |
| Ensembl ID | ENSRNOG00000007349 |
| Bio databases IDs | |
| Aliases | activating signal cointegrator 1 complex subunit 2 |
| Synonyms | 1700011I11Rik, 2610034L15Rik, activating signal cointegrator 1 complex subunit 2, ASC1p100, p100, RGD1561422 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ascc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- migraines
- schizophrenia
- idiopathic scoliosis
- bipolar disorder
- inflammatory bowel disease
- irritable bowel syndrome
regulates
- ASCC2
- ubiquitin
role in cell
- disassembly
- focus formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ribosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ascc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA dealkylation involved in DNA repair
- rescue of stalled ribosome
- DNA duplex unwinding
- ribosome disassembly
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- K63-linked polyubiquitin binding