Tpm2 Gene Summary [Rat]
Enables actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in actin filament organization; muscle contraction; and regulation of ATP-dependent activity. Located in actin cytoskeleton. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tpm2 |
| Official Name | tropomyosin 2 [Source:RGD Symbol;Acc:1559479] |
| Ensembl ID | ENSRNOG00000016731 |
| Bio databases IDs | |
| Aliases | tropomyosin 2 |
| Synonyms | AMCD1, Beta Tm, CMYO23, CMYP23, DA1, DA2B, DA2B4, EPITHELIAL TROPOMYOSIN, FIBROBLAST MUSCLE type TROPOMYOSIN, HEL-S-273, NEM4, TM2, TMSB, Trop-2, TROPOMYOSIN 2, tropomyosin 2, beta, Tropomyosin 2 (beta chain), tropomyosin 2, β, Tropomyosin 2 (β chain), β-TM, β-tropomyosin, β tropomyosin muscle |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tpm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Nuf2, DHR10-like domain
- Tropomyosin
- structural constituent of muscle
- Tropomyosin like
- structural constituent of cytoskeleton
- actin binding
- troponin T binding domain
- protein homodimerization
- protein binding
- identical protein binding
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Tpm2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- prostatic adenocarcinoma
- colorectal cancer
- rheumatoid arthritis
- hypertrophic scarring
- nemaline myopathy
- invasive breast carcinoma
- breast carcinoma
- invasive breast cancer
regulates
- F Actin
- fascin
- RHOA
- ATPase
role in cell
- growth
- formation
- differentiation
- migration
- assembly
- assembly in
- contact growth inhibition
- traction force
- maximum tension
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- cilia
- actin cytoskeleton
- myofilaments
- cytosol
- myofibrils
- I band
- Z line
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tpm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ATPase activity
- muscle contraction
- actin filament organization
Cellular Component
Where in the cell the gene product is active
- actin cytoskeleton
- cytosol
- muscle thin filament tropomyosin
- actin filament
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- identical protein binding
- protein homodimerization activity
- structural constituent of muscle
- actin binding
- protein heterodimerization activity