Capn9 Gene Summary [Rat]

Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Biomarker of hypertension. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human CAPN9 (calpain 9). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Capn9
Official Name
calpain 9 [Source:RGD Symbol;Acc:70965]
Ensembl ID
ENSRNOG00000018480
Bio databases IDs NCBI: 116694 Ensembl: ENSRNOG00000018480
Aliases calpain 9
Synonyms 2200003B16Rik, calpain 9, GC36, nCL-4
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Capn9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • The penta-EF hand (PEF) family
  • Calpain family cysteine protease
  • EF-hand domain
  • calpain
  • EF hand
  • peptidase
  • calcium ion binding
  • EFh
  • Calpain_III
  • CysPc

Pathways

Biological processes and signaling networks where the Capn9 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • BLD-2660
  • PRKN
disease
  • coronary artery disease
  • gastric cancer
  • pathologic myopia
regulated by
  • tetrachlorodibenzodioxin
  • PRDM2
  • CEACAM1
  • TP63
  • BLD-2660
  • 3,4,5,3',4'-pentachlorobiphenyl

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Capn9 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • proteolysis
  • digestion

Cellular Component

Where in the cell the gene product is active
  • cytoplasm

Molecular Function

What the gene product does at the molecular level
  • calcium ion binding
  • calcium-dependent cysteine-type endopeptidase activity

Gene-Specific Assays for Results You Can Trust

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