Ceacam1 Gene Summary [Rat]
Enables several functions, including bile acid transmembrane transporter activity; calmodulin binding activity; and protein homodimerization activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; insulin catabolic process; and regulation of signal transduction. Acts upstream of or within positive regulation of MAP kinase activity. Located in several cellular components, including adherens junction; basal plasma membrane; and lateral plasma membrane. Orthologous to several human genes including CEACAM1 (CEA cell adhesion molecule 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ceacam1 |
| Official Name | CEA cell adhesion molecule 1 [Source:RGD Symbol;Acc:67396] |
| Ensembl ID | ENSRNOG00000020578 |
| Bio databases IDs | |
| Aliases | CEA cell adhesion molecule 1 |
| Synonyms | BGP, BGP1, BGPA, BGPI, BGPR, Cc1, CCAM105, CD66a, CEACAM1-4L, CEA cell adhesion molecule 1, ecto-atpase, Ha4, HV2, MHV receptor, Pp120 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ceacam1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- extracellular domain
- protein kinase binding
- calmodulin binding
- immunoglobulin domain
- protein phosphatase binding
- signal peptide
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- granulocyte colony-stimulating factor receptor binding
- identical protein binding
- phosphorylation site
- cytoskeletal protein binding
- kinase binding
- cytoplasmic domain
- actin binding
- Immunoglobulin like
- transmembrane domain
- intracellular domain
- protein homodimerization
- bile acid transporter
- cytosolic tail domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- sepsis
- cancer
- non-small cell lung carcinoma
- systemic lupus erythematosus
- colon cancer
- epithelial cancer
- lung cancer
- gastroesophageal junction adenocarcinoma
role in cell
- proliferation
- binding
- apoptosis
- colony formation
- growth
- morphology
- expression in
- migration
- invasion by
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- cilia
- cell surface
- Extracellular Space
- apical compartment
- microvesicles
- cellular membrane
- intercellular junctions
- cell-cell contacts
- granules
- tertiary granule membrane
- specific granule membrane
- apical cell surfaces
- plasma membrane extracellular face
- apical membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
- lateral cell-cell contacts
- brush border
- cell-cell adherens junctions
- basement membrane
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ceacam1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- granulocyte colony-stimulating factor signaling pathway
- wound healing, spreading of cells
- insulin receptor internalization
- negative regulation of interleukin-1 production
- negative regulation of platelet aggregation
- cell adhesion
- homophilic cell adhesion
- regulation of epidermal growth factor receptor signaling pathway
- regulation of immune system process
- negative regulation of protein kinase activity
- regulation of endothelial cell differentiation
- cellular response to insulin stimulus
- integrin-mediated signaling pathway
- blood vessel development
- angiogenesis
- negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
- cell migration
- bile acid and bile salt transport
- negative regulation of fatty acid biosynthetic process
- negative regulation of cytotoxic T cell degranulation
- regulation of endothelial cell migration
- signal transduction
- regulation of blood vessel remodeling
- negative regulation of vascular permeability
- regulation of ERK1 and ERK2 cascade
- regulation of protein kinase B signaling cascade
- negative regulation of T cell receptor signaling pathway
- negative regulation of lipid biosynthetic process
- regulation of cell growth
- positive regulation of vasculogenesis
- negative regulation of T cell mediated cytotoxicity
- common myeloid progenitor cell proliferation
- regulation of cell migration
- negative regulation of hepatocyte proliferation
- negative regulation of granulocyte differentiation
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- T cell receptor complex
- plasma membrane
- cell surface
- microvillus membrane
- adherens junction
- basal plasma membrane
- cell-cell junction
- transport vesicle membrane
- extracellular vesicular exosome
- membrane
- cell junction
- apical plasma membrane
- tertiary granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- bile acid transmembrane transporter activity
- identical protein binding
- calmodulin binding
- protein homodimerization activity
- protein binding
- protein phosphatase binding
- actin binding
- protein dimerization activity
- kinase binding
- filamin binding