Det1 Gene Summary [Rat]
Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and protein-containing complex assembly. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human DET1 (DET1 partner of COP1 E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Det1 |
| Official Name | DET1 partner of COP1 E3 ubiquitin ligase [Source:RGD Symbol;Acc:1309793] |
| Ensembl ID | ENSRNOG00000018515 |
| Bio databases IDs | |
| Aliases | DET1 partner of COP1 E3 ubiquitin ligase |
| Synonyms | 2610034H20Rik, DET1 partner of COP1 E3 ubiquitin ligase, RGD1309793 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Det1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- binding protein
- protein binding activity, bridging
- protein binding
- De-etiolated protein 1 Det1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Det1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cullin-RING ubiquitin ligase complex
- Cul4A-RING ubiquitin ligase complex
- CUL4 RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding