Glmn Gene Summary [Rat]
Predicted to enable hepatocyte growth factor receptor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase inhibitor activity. Predicted to be involved in several processes, including negative regulation of T cell proliferation; regulation of gene expression; and vasculogenesis. Predicted to act upstream of or within several processes, including neural tube closure; positive regulation of interleukin-2 production; and regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; and Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in arteriovenous malformation; glomangioma; and glomus tumor. Orthologous to human GLMN (glomulin, FKBP associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Glmn |
| Official Name | glomulin, FKBP associated protein [Source:RGD Symbol;Acc:1588600] |
| Ensembl ID | ENSRNOG00000002054 |
| Bio databases IDs | |
| Aliases | glomulin, FKBP associated protein |
| Synonyms | 9330160J16Rik, FAP, FAP48, FAP68, FKBPAP, GLML, glomulin, FKBP associated protein, GVM, LOC102549395, VMGLOM |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Glmn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- hepatocyte growth factor receptor binding
- enzyme inhibitor activity
- protein binding
- enzyme regulator activity
- receptor binding
- Uncharacterized protein family, YAP/Alf4/glomulin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Glmn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phosphorylation
- neural tube closure
- negative regulation of T cell proliferation
- negative regulation of cell proliferation
- muscle cell differentiation
- cell surface receptor signaling pathway
- vasculogenesis
- positive regulation of cytokine production
- regulation of proteasomal ubiquitin-dependent protein catabolic process
- regulation of gene expression, epigenetic
- positive regulation of interleukin-2 production
Cellular Component
Where in the cell the gene product is active
- cullin-RING ubiquitin ligase complex
- cytoplasm
- Cul4A-RING ubiquitin ligase complex
- Cul2-RING ubiquitin ligase complex
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding
- hepatocyte growth factor receptor binding
- ubiquitin-protein ligase inhibitor activity
- receptor binding