DET1 Gene Summary [Human]
Enables ubiquitin ligase-substrate adaptor activity and ubiquitin protein ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and protein-containing complex assembly. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | DET1 |
| Official Name | DET1 partner of COP1 E3 ubiquitin ligase [Source:HGNC Symbol;Acc:HGNC:25477] |
| Ensembl ID | ENSG00000140543 |
| Bio databases IDs | |
| Aliases | DET1 partner of COP1 E3 ubiquitin ligase |
| Synonyms | 2610034H20Rik, DET1 partner of COP1 E3 ubiquitin ligase, RGD1309793 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DET1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- binding protein
- protein binding activity, bridging
- protein binding
- De-etiolated protein 1 Det1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DET1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cullin-RING ubiquitin ligase complex
- Cul4A-RING ubiquitin ligase complex
- CUL4 RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding