Pex5 Gene Summary [Rat]
Predicted to enable peroxisome targeting sequence binding activity; protein carrier chaperone; and small GTPase binding activity. Predicted to be involved in several processes, including establishment of protein localization to peroxisome; pexophagy; and protein tetramerization. Predicted to act upstream of or within several processes, including fatty acid metabolic process; mitochondrial membrane organization; and nervous system development. Located in peroxisomal membrane. Part of protein-containing complex. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 2A; peroxisome biogenesis disorder 2B; and rhizomelic chondrodysplasia punctata type 5. Orthologous to human PEX5 (peroxisomal biogenesis factor 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pex5 |
| Official Name | peroxisomal biogenesis factor 5 [Source:RGD Symbol;Acc:1307612] |
| Ensembl ID | ENSRNOG00000049203 |
| Bio databases IDs | |
| Aliases | peroxisomal biogenesis factor 5 |
| Synonyms | ESTM1, LOC100912079, LOC103690024, PBD2A, PBD2B, Peroxin-5, peroxisomal biogenesis factor 5, Pex5p, PTS1-BP, PTS1R, PXR1, PXR1P, RCDP5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pex5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peroxisome targeting sequence binding
- TPR repeat
- WXXXF/Y pentapeptide repeat motif
- peroxisome targeting signal-1 receptor
- PTS1 binding domain
- Tetratricopeptide repeats
- enzyme binding
- protein binding
- WDKLQ sequence
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- rhizomelic chondrodysplasia punctata type 5
- peroxisome biogenesis disorder 2B
- dyspnea
- peroxisome biogenesis disorder 2a (zellweger)
- colon cancer
- colon carcinoma
- colon epithelial cancer
- peroxisome biogenesis disorder
- muscle weakness
role in cell
- cell death
- apoptosis
- binding in
- migration
- differentiation
- response by
- development
- pexophagy
- pexophagy in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- peroxisomal matrix
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- cytosol
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pex5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into peroxisome matrix
- neuromuscular process
- macropexophagy
- cell development
- endoplasmic reticulum organization
- very long-chain fatty acid metabolic process
- cerebral cortex cell migration
- positive regulation of multicellular organism growth
- cerebral cortex neuron differentiation
- mitochondrial membrane organization
- fatty acid beta-oxidation
- neuron migration
- protein import into peroxisome membrane
- protein import into peroxisome matrix, docking
- negative regulation of protein complex assembly
- protein import into peroxisome matrix, receptor recycling
- cellular response to reactive oxygen species
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- cytoplasm
- mitochondrion
- membrane
- cytosol
- Golgi apparatus
- macromolecular complex
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- peroxisome matrix targeting signal-1 binding
- small GTPase binding
- peroxisome membrane targeting sequence binding
- peroxisome targeting sequence binding
- enzyme binding