B3gnt3 Gene Summary [Rat]
Predicted to enable N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity. Predicted to be involved in poly-N-acetyllactosamine biosynthetic process and protein O-linked glycosylation. Predicted to be active in Golgi membrane. Orthologous to human B3GNT3 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | B3gnt3 |
| Official Name | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 [Source:RGD Symbol;Acc:1305151] |
| Ensembl ID | ENSRNOG00000018764 |
| Bio databases IDs | |
| Aliases | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 |
| Synonyms | 2210008L19Rik, B3GAL-T8, beta3Gn-T3, Core1 beta3 glcnact, HP10328, TMEM3, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, UDP-GlcNAc:betaGal β-1,3-N-acetylglucosaminyltransferase 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat B3gnt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
- UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase
- galactosyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphomagenesis
- uterine serous papillary cancer
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- streptococcal pharyngitis
- primary cancer
- primary central nervous system lymphoma
- central nervous system cancer
regulates
- keratan sulfate
- poly-N-acetyllactosamine
- focal adhesion kinase
- O-glycan
- beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R-group
role in cell
- growth
- ferroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat B3gnt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein O-linked glycosylation
- O-glycan processing
- keratan sulfate biosynthetic process
- poly-N-acetyllactosamine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
- UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity