Sftpc Gene Summary [Rat]
Enables identical protein binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to vitamin A. Located in alveolar lamellar body; extracellular space; and multivesicular body. Biomarker of bacterial pneumonia and newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); and respiratory syncytial virus infectious disease. Orthologous to human SFTPC (surfactant protein C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sftpc |
| Official Name | surfactant protein C [Source:RGD Symbol;Acc:3666] |
| Ensembl ID | ENSRNOG00000011177 |
| Bio databases IDs | |
| Aliases | surfactant protein C |
| Synonyms | BRICD6, pro-SpC, PSP-C, SFTP2, SMDP2, SP5, SP-C, surfactant associated protein C, surfactant protein C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sftpc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pulmonary surfactant proteins
- Surfactant protein C, N terminal propeptide
- protein binding
- BRICHOS domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- neoplasia
- lung cancer
- COVID-19
- pulmonary emphysema
- organismal death
- surfactant metabolism dysfunction due to protein C deficiency
- congenital pulmonary alveolar proteinosis
- hereditary disorder
- weight loss
role in cell
- expression in
- phosphorylation in
- binding in
- apoptosis
- activation in
- cell death
- proliferation
- quantity
- differentiation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cellular membrane
- endosomes
- vesicles
- lysosome
- endoplasmic reticulum membrane
- alveolar epithelial lamellar bodies
- cytoplasmic vesicles
- endocytotic vesicle
- multivesicular bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sftpc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- respiratory gaseous exchange
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- alveolar lamellar body
- clathrin-coated endocytic vesicle
- extracellular region
- lamellar body
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding