Jph3 Gene Summary [Rat]
Predicted to be involved in several processes, including exploration behavior; memory; and regulation of ryanodine-sensitive calcium-release channel activity. Predicted to act upstream of or within several processes, including learning; neuromuscular process controlling balance; and regulation of neuronal synaptic plasticity. Predicted to be located in endoplasmic reticulum. Predicted to be part of junctional membrane complex. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Human ortholog(s) of this gene implicated in Huntington's disease-like 2. Orthologous to human JPH3 (junctophilin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Jph3 |
| Official Name | junctophilin 3 [Source:RGD Symbol;Acc:1308416] |
| Ensembl ID | ENSRNOG00000018784 |
| Bio databases IDs | |
| Aliases | junctophilin 3 |
| Synonyms | CAGL237, HDL2, JP-3, junctophilin 3, TNRC22 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Jph3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane Occupation and Recognition Nexus motif
- MORN repeat
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lewy body disease
- schizophrenia
- bipolar disorder
- breast cancer
- infertility condition
- osteoarthritis
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- colon epithelial cancer
regulated by
- TRIM37
- levodopa
- Large T Antigen
- estrogen receptor
regulates
- Ca2+
- CaMKII
role in cell
- plasticity
- necroptosis
- long-term potentiation
- transport in
- excitatory postsynaptic potential
- afterhyperpolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- junctional membrane complex
- cellular membrane
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Jph3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- exploration behavior
- locomotion
- regulation of neuronal synaptic plasticity
- regulation of synaptic plasticity
- learning
- memory
- calcium ion transport into cytosol
- neuromuscular process controlling balance
- regulation of ryanodine-sensitive calcium-release channel activity
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- junctional sarcoplasmic reticulum membrane
- junctional membrane complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding