Brk1 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to contribute to small GTPase binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; positive regulation of cellular component organization; and regulation of actin polymerization or depolymerization. Predicted to act upstream of or within actin cytoskeleton organization; in utero embryonic development; and positive regulation of fibroblast proliferation. Predicted to be located in lamellipodium. Predicted to be part of SCAR complex. Orthologous to human BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brk1 |
| Official Name | BRICK1 subunit of SCAR/WAVE actin nucleating complex [Source:RGD Symbol;Acc:1598136] |
| Ensembl ID | ENSRNOG00000010184 |
| Bio databases IDs | |
| Aliases | BRICK1 subunit of SCAR/WAVE actin nucleating complex |
| Synonyms | 6720456B07Rik, BRICK1, SCAR/WAVE actin-nucleating complex subunit, BRICK1 subunit of SCAR/WAVE actin nucleating complex, C3orf10, hHBrk1, HSPC300, LOC687498, MDS027 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Brk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- enzyme binding
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Brk1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal cancer
- bladder cancer
- neoplastic cell transformation
regulates
- ARP2/3
- zymosan
- protein-protein complex
- Myelin
- actin
- VCL
role in cell
- migration
- proliferation
- growth
- assembly
- formation
- motility
- phagocytosis by
- formation in
- phagocytosis
- distribution in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Brk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Rac protein signal transduction
- positive regulation of lamellipodium assembly
- cell motility
- fibroblast proliferation
- in utero embryonic development
- positive regulation of fibroblast proliferation
- regulation of actin polymerization or depolymerization
- actin filament organization
- positive regulation of Arp2/3 complex-mediated actin nucleation
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- SCAR complex
- cytoskeleton
- extracellular vesicular exosome
- cytosol
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- small GTPase binding