Stk16 Gene Summary [Rat]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase activity. Involved in cellular response to transforming growth factor beta stimulus; positive regulation of transcription by RNA polymerase II; and protein autophosphorylation. Predicted to be located in several cellular components, including Golgi-associated vesicle; cytosol; and nuclear body. Predicted to be active in Golgi apparatus. Orthologous to human STK16 (serine/threonine kinase 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stk16 |
| Official Name | serine/threonine kinase 16 [Source:RGD Symbol;Acc:629474] |
| Ensembl ID | ENSRNOG00000019294 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 16 |
| Synonyms | EDPK, F52, hPSK, KRCT, MGC16211, MPSK, PKL12, PSK, serine/threonine kinase 16, TSF-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stk16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- nucleic acid binding
- protein binding
- Protein kinase domain
- sequence-specific DNA binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- double-stranded DNA binding
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Golgi region
- cellular membrane
- Plasma Membrane
- vesicles
- Golgi Apparatus
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stk16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to transforming growth factor beta stimulus
- protein autophosphorylation
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- Golgi apparatus
- Golgi-associated vesicle
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- protein serine/threonine kinase activity