Adamts19 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including collagen fibril organization; heart valve morphogenesis; and ventricular septum morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human ADAMTS19 (ADAM metallopeptidase with thrombospondin type 1 motif 19). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adamts19 |
| Official Name | ADAM metallopeptidase with thrombospondin type 1 motif, 19 [Source:RGD Symbol;Acc:1308359] |
| Ensembl ID | ENSRNOG00000019577 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase with thrombospondin type 1 motif, 19 |
| Synonyms | 4831407I23Rik, ADAM metallopeptidase with thrombospondin type 1 motif 19, ADAM metallopeptidase with thrombospondin type 1 motif, 19, CVDP2, D230034E10RIK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adamts19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Reprolysin family propeptide
- Thrombospondin type 1 domain
- ADAM-TS Spacer 1
- ZnMc
- Metallo-peptidase family M12B Reprolysin-like
- ADAMTS cysteine-rich domain 2
- peptidase
- Reprolysin (M12B) family zinc metalloprotease
- Spondin-like TSP1 domain
Pathways
Biological processes and signaling networks where the Adamts19 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- cardiac valvular dysplasia type 2
- idiopathic scoliosis
- major depression
- congenital heart disease
- acute myeloid leukemia
- open-angle glaucoma
- sexual disorder
- Dupuytren contracture
- diabetic nephropathy
regulated by
- dexamethasone
- ASXL3
role in cell
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adamts19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- aortic valve morphogenesis
- mitral valve morphogenesis
- proteolysis
- pulmonary valve morphogenesis
- extracellular matrix organization
- tricuspid valve morphogenesis
- collagen fibril organization
- ventricular septum morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- metalloendopeptidase activity