Gdf15 Gene Summary [Rat]
Enables protein homodimerization activity. Predicted to be involved in several processes, including GDF15-GFRAL signaling pathway; reduction of food intake in response to dietary excess; and regulation of signal transduction. Predicted to act upstream of or within positive regulation of myoblast fusion. Located in extracellular region. Orthologous to human GDF15 (growth differentiation factor 15). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gdf15 |
| Official Name | growth differentiation factor 15 [Source:RGD Symbol;Acc:2674] |
| Ensembl ID | ENSRNOG00000019661 |
| Bio databases IDs | |
| Aliases | growth differentiation factor 15 |
| Synonyms | growth differentiation factor 15, HG, LOC100292463, MIC-1, NAG-1, PDF, PLAB, Placental TGF-beta, Placental TGF-β, PROSTATE DIFFERENTIATION FACTOR, PTGFB, Ptgf β, SBF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gdf15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TGF_beta_SF
- protein homodimerization
- Transforming growth factor beta like domain
- hormone
- protein binding
- cytokine
- growth factor
Pathways
Biological processes and signaling networks where the Gdf15 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- adenoma formation
- breast cancer
- hypertension
- neoplasia
- susceptibility to hyperemesis gravidarum
- colon neoplasm
- colorectal neoplasia
- atherosclerosis
role in cell
- production in
- activation in
- expression in
- phosphorylation in
- proliferation
- morphology
- growth
- apoptosis
- cell viability
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular compartment
- Cytoplasm
- intracellular space
- membrane surface
- Nucleus
- Golgi Apparatus
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gdf15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of multicellular organism growth
- negative regulation of SMAD protein import into nucleus
- negative regulation of appetite
- signal transduction
- cell-cell signaling
- transforming growth factor beta receptor signaling pathway
- positive regulation of MAPK cascade
- negative regulation of growth hormone receptor signaling pathway
- reduction of food intake in response to dietary excess
- negative regulation of leukocyte migration
- positive regulation of fatty acid oxidation
- positive regulation of protein kinase B signaling cascade
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- Golgi apparatus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- protein homodimerization activity
- cytokine activity
- hormone activity