Nlgn3 Gene Summary [Rat]
Enables cell adhesion molecule binding activity; neurexin family protein binding activity; and signaling receptor activity. Involved in several processes, including inhibitory postsynaptic potential; neuron cell-cell adhesion; and synapse assembly. Acts upstream of or within synapse organization. Located in several cellular components, including excitatory synapse; inhibitory synapse; and postsynaptic membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization membrane. Used to study autism spectrum disorder. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human NLGN3 (neuroligin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nlgn3 |
| Official Name | neuroligin 3 [Source:RGD Symbol;Acc:621119] |
| Ensembl ID | ENSRNOG00000003812 |
| Bio databases IDs | |
| Aliases | neuroligin 3 |
| Synonyms | A230085M13Rik, HNL3, neuroligin 3, NL-3, NLG3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nlgn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Carboxylesterase family
- signaling receptor activity
- cytoplasmic domain
- alpha/beta hydrolases
- alpha/beta hydrolase fold domain
- cell adhesion molecule binding
- neurexin binding
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypogonadotropic hypogonadism
- susceptibility to X-linked autism type 1
- pervasive developmental disorder
- hereditary disorder
- X-linked complex neurodevelopmental disorder
- polycystic kidney disease
- mental retardation
- Asperger syndrome
- autism
- productive infection by HIV-1
role in cell
- number
- expression in
- differentiation
- synaptic transmission
- formation
- organization
- assembly
- morphogenesis
- plasticity
- sphere formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- synapse
- endocytotic vesicle
- perikaryon
- dendrites
- inhibitory synapse
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nlgn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- rhythmic synaptic transmission
- synapse organization
- positive regulation of glutamate receptor signaling pathway
- neuron cell-cell adhesion
- synaptic transmission
- regulation of respiratory gaseous exchange by neurological system process
- learning
- receptor-mediated endocytosis
- synapse assembly
- postsynaptic membrane assembly
- synaptic vesicle endocytosis
- axon extension
- presynaptic membrane assembly
- regulation of inhibitory postsynaptic membrane potential
- regulation of synaptic transmission
- positive regulation of excitatory postsynaptic membrane potential
- positive regulation of synaptic transmission, glutamatergic
- positive regulation of synapse assembly
- adult behavior
- vocalization behavior
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- postsynaptic membrane
- excitatory synapse
- membrane
- synapse
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- protein binding
- cell adhesion molecule binding
- signaling receptor activity
- neurexin family protein binding