B3gat3 Gene Summary [Rat]
The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans. A pseudogene of this gene has been identified on chromosome 3. [provided by RefSeq, Dec 2013]
Details
| Type | Protein Coding |
| Official Symbol | B3gat3 |
| Official Name | beta-1,3-glucuronyltransferase 3 [Source:RGD Symbol;Acc:1311968] |
| Ensembl ID | ENSRNOG00000019804 |
| Bio databases IDs | |
| Aliases | beta-1,3-glucuronyltransferase 3 |
| Synonyms | 2810405M13Rik, beta-1,3-glucuronyltransferase 3, GLCATI, GlcUAT-I, glucuronosyltransferase I, JDSCD, β-1,3-glucuronyltransferase 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat B3gat3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 43
- galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
- protein phosphatase regulator
- enzyme
- phosphatase activator
- protein binding
- glycosyltransferase family A
- glucuronosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Golgi Apparatus
- Mitochondria
- Golgi membrane
- cis Golgi networks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat B3gat3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- positive regulation of intracellular protein transport
- chondroitin sulfate proteoglycan biosynthetic process
- dermatan sulfate proteoglycan biosynthetic process
- heparan sulfate proteoglycan biosynthetic process
- positive regulation of catalytic activity
- protein glycosylation
- glycosaminoglycan biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cis-Golgi network
- extracellular vesicular exosome
- membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- protein phosphatase activator activity
- glucuronosyltransferase activity
- galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity