B3gat3 Gene Summary [Mouse]
Predicted to enable galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity and protein phosphatase activator activity. Involved in glycosaminoglycan biosynthetic process. Predicted to be located in cis-Golgi network. Predicted to be active in Golgi membrane. Is expressed in several structures, including cranium; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Larsen-like syndrome B3GAT3 type. Orthologous to human B3GAT3 (beta-1,3-glucuronyltransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | B3gat3 |
| Official Name | beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) [Source:MGI Symbol;Acc:MGI:1919977] |
| Ensembl ID | ENSMUSG00000071649 |
| Bio databases IDs | |
| Aliases | beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) |
| Synonyms | 2810405M13Rik, beta-1,3-glucuronyltransferase 3, GLCATI, GlcUAT-I, glucuronosyltransferase I, JDSCD, β-1,3-glucuronyltransferase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse B3gat3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 43
- galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
- protein phosphatase regulator
- enzyme
- phosphatase activator
- protein binding
- glycosyltransferase family A
- glucuronosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Golgi Apparatus
- Mitochondria
- Golgi membrane
- cis Golgi networks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse B3gat3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- positive regulation of intracellular protein transport
- chondroitin sulfate proteoglycan biosynthetic process
- dermatan sulfate proteoglycan biosynthetic process
- heparan sulfate proteoglycan biosynthetic process
- positive regulation of catalytic activity
- protein glycosylation
- glycosaminoglycan biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cis-Golgi network
- extracellular vesicular exosome
- membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- protein phosphatase activator activity
- glucuronosyltransferase activity
- galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity