Hyal2 Gene Summary [Rat]
Enables hyaluronoglucuronidase activity. Involved in several processes, including hyaluronan catabolic process; positive regulation of urine volume; and renal water absorption. Located in Golgi membrane; membrane raft; and plasma membrane. Biomarker of pulmonary hypertension. Orthologous to human HYAL2 (hyaluronidase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hyal2 |
| Official Name | hyaluronidase 2 [Source:RGD Symbol;Acc:620321] |
| Ensembl ID | ENSRNOG00000031420 |
| Bio databases IDs | |
| Aliases | hyaluronidase 2 |
| Synonyms | hyaluronidase 2, hyaluronoglucosaminidase 2, LUCA2, MCCS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hyal2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription co-activator
- receptor signaling protein tyrosine kinase inhibitor activity
- viral receptor
- receptor tyrosine kinase binding
- hyaluronoglucuronidase
- enzyme binding
- enzyme
- protein binding
- hyalurononglucosaminidase
- hyaluronic acid binding
- TGFbeta binding
- hyaluronidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- osteoarthritis
- Muggenthaler-Chowdhury-Chioza syndrome
- knee osteoarthritis
- hypoplasia
- peri-implantitis
- glaucoma
- endometriosis
- prostatic disease
- dry eye
role in cell
- apoptosis
- growth
- differentiation
- migration
- activation
- quantity
- number
- activation in
- transformation
- entrance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Plasma Membrane
- endosomes
- lysosome
- granules
- cytosol
- plasma membrane extracellular face
- apical membrane
- Golgi membrane
- growth cone
- cytoplasmic vesicles
- endocytotic vesicle
- membrane rafts
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hyal2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- multicellular organismal iron ion homeostasis
- negative regulation of MAP kinase activity
- negative regulation of protein tyrosine kinase activity
- response to antibiotic
- response to virus
- positive regulation of transcription from RNA polymerase II promoter
- hemopoietic progenitor cell differentiation
- monocyte activation
- glycosaminoglycan catabolic process
- cellular response to UV-B
- negative regulation of cell growth
- kidney development
- viral envelope fusion with host membrane
- defense response to virus
- cellular response to tumor necrosis factor
- positive regulation of urine volume
- positive regulation of protein import into nucleus
- positive regulation of inflammatory response
- cellular response to fibroblast growth factor stimulus
- response to reactive oxygen species
- skeletal system morphogenesis
- cellular response to transforming growth factor beta stimulus
- carbohydrate metabolic process
- renal water absorption
- positive regulation of interleukin-8 production
- cellular response to interleukin-1
- negative regulation of fibroblast migration
- positive regulation of extrinsic apoptotic signaling pathway
- positive regulation of interleukin-6 production
- cartilage development
- negative regulation of protein kinase B signaling cascade
- hyaluronan catabolic process
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- endoplasmic reticulum
- Golgi membrane
- plasma membrane
- lysosome
- cell surface
- endocytic vesicle
- perinuclear region of cytoplasm
- cytoplasm
- microvillus
- membrane raft
- cytoplasmic vesicle
- cytosol
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- transforming growth factor beta binding
- protein binding
- hyalurononglucosaminidase activity
- transcription coactivator activity
- hyaluronoglucuronidase activity
- receptor signaling protein tyrosine kinase inhibitor activity
- viral receptor activity
- hyaluronic acid binding
- receptor tyrosine kinase binding
- enzyme binding