Folr2 Gene Summary [Rat]
Predicted to enable folic acid binding activity; folic acid receptor activity; and signaling receptor activity. Involved in positive regulation of gene expression. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. Orthologous to several human genes including FOLR2 (folate receptor beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Folr2 |
| Official Name | folate receptor beta [Source:RGD Symbol;Acc:1308515] |
| Ensembl ID | ENSRNOG00000019890 |
| Bio databases IDs | |
| Aliases | folate receptor beta |
| Synonyms | BETA-HFR, FBP, FBP2, FBP/PL-1, folate receptor beta, Folate receptor foetal, folate receptor β, Folbp-2, FOLR1, FR-BETA, FR-P3, FR-β, β-HFR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Folr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cargo receptor activity
- folic acid binding
- Folate receptor family
- glycosylphosphatidylinositol anchor sequence
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic pulmonary fibrosis
- lichen planus
- colorectal cancer
- Alzheimer disease
- limited systemic sclerosis
regulates
- folic acid
role in cell
- proliferation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Folr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- folic acid transport
- inflammatory response
- sperm-egg recognition
- monocyte chemotaxis
- cellular response to folic acid
- positive regulation of cell proliferation
- fusion of sperm to egg plasma membrane
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- signaling receptor activity
- folic acid binding