Sp1 Gene Summary [Rat]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; histone acetyltransferase binding activity; and transcription coregulator binding activity. Involved in several processes, including cellular response to estrogen stimulus; cellular response to wortmannin; and cellular response to zinc ion starvation. Located in chromatin and nucleus. Part of protein-DNA complex. Orthologous to human SP1 (Sp1 transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sp1 |
| Official Name | Sp1 transcription factor [Source:RGD Symbol;Acc:3738] |
| Ensembl ID | ENSRNOG00000014084 |
| Bio databases IDs | |
| Aliases | Sp1 transcription factor |
| Synonyms | 1110003E12RIK, Sp1-1, Sp1 transcription factor, Sp1 (trans spliced isoform), Trans-acting transcription factor 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger DNA binding domain
- transcription regulator
- transcription activation domain
- transcription factor binding
- glutamine-rich domain
- identical protein binding
- C2H2-type zinc finger
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Caspase 3 cleavage site
- Zinc-finger double domain
- N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
- A domain
- histone acetyltransferase binding
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- DNA binding domain
- nucleic acid binding
- oligomerization domain
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- zinc finger
- double-stranded DNA binding
- protein homodimerization
- histone H3 binding domain
- histone deacetylase binding domain
- serine threonine rich domain
- Sp1 D domain
- zinc finger domain
- transcription factor activity
- serine threonine glutamine rich activation domain
Pathways
Biological processes and signaling networks where the Sp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Endothelial Signaling Pathway
- Aryl Hydrocarbon Receptor Signaling
- BER pathway
- DNA Methylation and Transcriptional Repression Signaling
- ErbB2-ErbB3 Signaling
- Estrogen Receptor Signaling
- Estrogen-Dependent Breast Cancer Signaling
- Gap Junction Signaling
- HER-2 Signaling in Breast Cancer
- HMGB1 Signaling
- Huntington's Disease Signaling
- IL-10 Signaling
- Osteoarthritis Pathway
- Prolactin Signaling
- RAR Activation
- Role of PKR in Interferon Induction and Antiviral Response
- Sirtuin Signaling Pathway
- Telomerase Signaling
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- hypertension
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- metastasis
- malignant pleural mesothelioma
- pleural cancer
- mesothelioma formation
role in cell
- binding in
- cell death
- apoptosis
- expression in
- phosphorylation in
- activation in
- invasion by
- proliferation
- migration
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- nuclear matrix fraction
- membrane fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear matrix
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation by host of viral transcription
- response to hydroperoxide
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- cellular response to estrogen stimulus
- positive regulation of blood vessel endothelial cell migration
- positive regulation of angiogenesis
- regulation of transcription from RNA polymerase II promoter
- cellular response to insulin stimulus
- rhythmic process
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- cellular response to zinc ion starvation
Cellular Component
Where in the cell the gene product is active
- nucleus
- euchromatin
- cytoplasm
- transcriptional repressor complex
- protein-DNA complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- histone acetyltransferase binding
- protein homodimerization activity
- histone deacetylase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- double-stranded DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- bHLH transcription factor binding
- DNA binding
- transcription cofactor binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- binding, bridging