Folr2 Gene Summary [Mouse]
This gene encodes a receptor protein located on the plasma membrane that mediates folate uptake by cells. Mice lacking the product of this gene show no defects in embryonic development and grow normally into fertile adults. However, such mice were found to be highly susceptible to the teratogenic effects of arsenic. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | Folr2 |
| Official Name | folate receptor 2 (fetal) [Source:MGI Symbol;Acc:MGI:95569] |
| Ensembl ID | ENSMUSG00000032725 |
| Bio databases IDs | |
| Aliases | folate receptor 2 (fetal) |
| Synonyms | BETA-HFR, FBP, FBP2, FBP/PL-1, folate receptor beta, Folate receptor foetal, folate receptor β, Folbp-2, FOLR1, FR-BETA, FR-P3, FR-β, β-HFR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Folr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cargo receptor activity
- folic acid binding
- Folate receptor family
- glycosylphosphatidylinositol anchor sequence
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic pulmonary fibrosis
- lichen planus
- colorectal cancer
- Alzheimer disease
- limited systemic sclerosis
regulates
- folic acid
role in cell
- proliferation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Folr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- folic acid transport
- inflammatory response
- sperm-egg recognition
- monocyte chemotaxis
- cellular response to folic acid
- positive regulation of cell proliferation
- fusion of sperm to egg plasma membrane
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- signaling receptor activity
- folic acid binding