Sars1 Gene Summary [Rat]
Predicted to enable several functions, including aminoacyl-tRNA ligase activity; protein homodimerization activity; and tRNA binding activity. Predicted to be involved in several processes, including negative regulation of angiogenesis; negative regulation of macromolecule biosynthetic process; and translation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sars1 |
| Official Name | seryl-tRNA synthetase 1 [Source:RGD Symbol;Acc:628813] |
| Ensembl ID | ENSRNOG00000020255 |
| Bio databases IDs | |
| Aliases | seryl-tRNA synthetase 1 |
| Synonyms | NEDMAS, SARS, Serine--tRNA ligase, SERRS, SERS, seryl-tRNA synthetase 1, Seryl-tRNA Synthetase, Cytoplasmic, Strs |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sars1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- class_II_aaRS-like_core
- Seryl-tRNA synthetase N-terminal domain
- nucleic acid binding
- enzyme binding
- enzyme
- protein binding
- sequence-specific DNA binding
- serine-tRNA ligase
- tRNA synthetase class II core domain (G, H, P, S and T)
- double-stranded DNA binding
- protein homodimerization
- seryl-tRNA synthetase
- tRNA ligase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with microcephaly, ataxia and seizures
- intracranial arteriovenous malformation
regulates
- DNA endogenous promoter
- RNA polymerase II
- selenocysteine
- DNA promoter
- tRNA-Ser
role in cell
- migration
- translation in
- sprouting
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sars1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of angiogenesis
- selenocysteine incorporation
- cytoplasmic translation
- tRNA modification
- seryl-tRNA aminoacylation
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein homodimerization activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- serine-tRNA ligase activity
- tRNA binding
- enzyme binding
- binding, bridging