Sh3gl1 Gene Summary [Rat]
Enables several functions, including SH3 domain binding activity; beta-1 adrenergic receptor binding activity; and enzyme binding activity. Involved in modulation of excitatory postsynaptic potential and positive regulation of synaptic vesicle endocytosis. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density, intracellular component. Used to study high grade glioma. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Orthologous to human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh3gl1 |
| Official Name | SH3 domain containing GRB2 like 1, endophilin A2 [Source:RGD Symbol;Acc:708456] |
| Ensembl ID | ENSRNOG00000049683 |
| Bio databases IDs | |
| Aliases | SH3 domain containing GRB2 like 1, endophilin A2 |
| Synonyms | CNSA1, EEN, Endophilin a1, Endophilin A2, LOC81922, SH3D2B, SH3 domain containing GRB2 like 1, endophilin A2, SH3 domain GRB2-LIKE 1, SH3P8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sh3gl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- ion channel binding
- enzyme binding
- coiled-coil domain
- BAR domain
- protein binding
- Bin/amphiphysin/Rvs domain for vesicular trafficking
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- SH3-domain binding
- Src Homology 3 domain superfamily
- phosphatase binding
Pathways
Biological processes and signaling networks where the Sh3gl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- renal fibrosis
- dyspnea
- kidney disease
- rheumatoid arthritis
- neurodegeneration
- acute myeloid leukemia
- growth failure
- seizures
- arthritis
role in cell
- proliferation
- growth
- expression in
- phosphorylation in
- apoptosis
- accumulation in
- accumulation
- abnormal morphology
- transformation
- self-renewal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- organelle
- presynaptic regions
- cell periphery
- cytosol
- nerve ending
- synapse
- axosomatic synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sh3gl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic vesicle uncoating
- central nervous system development
- signal transduction
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- anchoring junction
- cytoplasm
- cytosol
- cell projection
- podosome
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cadherin binding
- lipid binding