Slc22a18 Gene Summary [Rat]
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Predicted to be located in apical plasma membrane and cytoplasm. Predicted to be active in nuclear envelope. Human ortholog(s) of this gene implicated in breast cancer; esophagus adenocarcinoma; and lung cancer. Orthologous to human SLC22A18 (solute carrier family 22 member 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc22a18 |
| Official Name | solute carrier family 22, member 18 [Source:RGD Symbol;Acc:1303323] |
| Ensembl ID | ENSRNOG00000020562 |
| Bio databases IDs | |
| Aliases | solute carrier family 22, member 18 |
| Synonyms | AW260131, BWR1A, BWSCR1A, HET, IMPT, IMPT1, ITM, ORCTL2, p45-BWR1A, SLC22A1L, solute carrier family 22 member 18, solute carrier family 22, member 18, solute carrier family 22 (organic cation transporter), member 18, TSSC5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc22a18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- xenobiotic transporter
- Major Facilitator Superfamily
- protein binding
- organic anion transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- non-insulin-dependent diabetes mellitus
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
- lung adenocarcinoma formation
- EGFR expression positive non-squamous non-small cell lung cancer
- epithelial neoplasia
- breast cancer
- epithelial cancer
- soft tissue sarcoma cancer
regulates
- triacylglycerol
- anion
- SLC22A18
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- apical membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc22a18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- organic cation transport
- xenobiotic transport
- transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- cytoplasm
- membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- xenobiotic transporter activity
- protein binding
- ubiquitin protein ligase binding
- symporter activity