C3ar1 Gene Summary [Rat]
Enables complement component C3a binding activity and complement component C3a receptor activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of cell population proliferation; and tolerance induction to nonself antigen. Predicted to be active in plasma membrane. Used to study adult respiratory distress syndrome. Biomarker of asthma and lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human C3AR1 (complement C3a receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | C3ar1 |
| Official Name | complement C3a receptor 1 [Source:RGD Symbol;Acc:620537] |
| Ensembl ID | ENSRNOG00000009211 |
| Bio databases IDs | |
| Aliases | complement C3a receptor 1 |
| Synonyms | AZ3B, C3AR, complement C3a receptor 1, complement component 3a receptor 1, HNFAG09, Hs.567242 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C3ar1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- complement component C3a receptor
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the C3ar1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- epithelial cancer
- cancer
- colon cancer
- osteoarthritis
- peripheral arterial disease
- hypersensitivity reaction type I
- experimental membranous nephropathy
- endotoxemia
- bronchoconstriction
role in cell
- expression in
- accumulation in
- phosphorylation in
- apoptosis
- activation in
- cellular infiltration by
- proliferation
- number
- growth
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- lysosome
- secretory granule membrane
- specific granule membrane
- apical membrane
- basolateral membrane
- lysosome membrane
- periplasmic membranes
- cytoplasmic vesicles
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C3ar1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- positive regulation of neutrophil chemotaxis
- blood circulation
- phospholipase C-activating G-protein coupled receptor signaling pathway
- complement receptor mediated signaling pathway
- positive regulation of angiogenesis
- elevation of cytosolic calcium ion concentration
- chemotaxis
- inflammatory response
- positive regulation of macrophage chemotaxis
- calcium-mediated signaling
- positive regulation vascular endothelial growth factor production
Cellular Component
Where in the cell the gene product is active
- azurophil granule membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- complement component C3a receptor activity
- G-protein coupled receptor activity
- complement component C5a receptor activity