Gys1 Gene Summary [Rat]
Enables D-glucose binding activity and alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity. Involved in glycogen biosynthetic process. Predicted to be located in inclusion body. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in cardiovascular system disease. Orthologous to human GYS1 (glycogen synthase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gys1 |
| Official Name | glycogen synthase 1 [Source:RGD Symbol;Acc:1589798] |
| Ensembl ID | ENSRNOG00000020812 |
| Bio databases IDs | |
| Aliases | glycogen synthase 1 |
| Synonyms | GLYCOGEN SYNTHASE, glycogen synthase 1, glycogen synthase 1, muscle, GSY, GYS, GYS3, LOC687978, MGS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gys1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosyltransferase family 1 and related proteins with GTB topology
- phosphotransferase
- glucose binding
- glycogen(starch) synthase
- enzyme
- protein binding
- Glycogen synthase
Pathways
Biological processes and signaling networks where the Gys1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- muscle glycogen storage disease type 0
- astrocytosis
- glycogen storage disease
- cutaneous melanoma
- cutaneous melanoma cancer
- microgliosis
regulates
- glycogen
- glycogen synthase
- PP1
- 18F-N-(methyl-(2-fluoroethyl)-1H-[1,2,3]triazole-4-yl)glucosamine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- intracellular space
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gys1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- glycogen biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- inclusion body
Molecular Function
What the gene product does at the molecular level
- glucose binding
- protein binding
- glycogen (starch) synthase activity