Irs2 Gene Summary [Rat]
Enables several functions, including 14-3-3 protein binding activity; insulin receptor binding activity; and phosphatidylinositol 3-kinase binding activity. Involved in cellular response to endothelin; cellular response to glucose stimulus; and insulin receptor signaling pathway. Predicted to be active in cytosol and plasma membrane. Biomarker of metabolic dysfunction-associated steatotic liver disease and osteoporosis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Irs2 |
| Official Name | insulin receptor substrate 2 [Source:RGD Symbol;Acc:69316] |
| Ensembl ID | ENSRNOG00000023509 |
| Bio databases IDs | |
| Aliases | insulin receptor substrate 2 |
| Synonyms | 4PS, insulin receptor substrate 2, LOC207125 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Irs2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PI3K binding domain
- insulin receptor binding
- protein kinase binding
- Kinase regulatory loop binding domain
- PTB domain (IRS-1 type)
- protein phosphatase binding
- protein binding activity, bridging
- protein domain specific binding
- enzyme
- phosphoinositide 3-kinase regulator
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- insulin Receptor recognition domain
- phosphoinositide 3-kinase binding
- PH domain
- SAIN domain
- transmembrane receptor protein tyrosine kinase adaptor protein
Pathways
Biological processes and signaling networks where the Irs2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Autophagy
- Erythropoietin Signaling
- GDNF Family Ligand-Receptor Interactions
- IGF-1 Signaling
- IL-4 Signaling
- IL-9 Signaling
- ILK Signaling
- Insulin Receptor Signaling
- PI3K Signaling in B Lymphocytes
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- Thrombopoietin Signaling
- Thyroid Cancer Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- endometriosis
- diabetes mellitus
- hyperglycemia
- insulin-dependent diabetes mellitus
- non-insulin-dependent diabetes mellitus
- weight loss
- Alzheimer disease
- insulin resistance
- obesity
role in cell
- proliferation
- apoptosis
- binding in
- survival
- number
- migration
- phosphorylation in
- formation in
- expression in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- high-density microsomal fractions
- low-density microsomal fraction
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- membrane ruffles
- smooth microsomes
- perikaryon
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Irs2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin receptor signaling pathway
- positive regulation of cell proliferation
- glucose metabolic process
- positive regulation of glycogen biosynthetic process
- cellular response to insulin stimulus
- response to glucose stimulus
- cellular response to glucose stimulus
- type B pancreatic cell proliferation
- positive regulation of epithelial cell migration
- negative regulation of kinase activity
- positive regulation of insulin secretion
- epithelial cell migration
- signal transduction
- positive regulation of fatty acid beta-oxidation
- lipid homeostasis
- positive regulation of glucose import
- positive regulation of mesenchymal cell proliferation
- brain development
- mammary gland development
- positive regulation of glucose metabolic process
- negative regulation of plasma membrane long-chain fatty acid transport
- negative regulation of B cell apoptotic process
- positive regulation of B cell proliferation
- regulation of lipid metabolic process
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol 3-kinase binding
- protein domain specific binding
- protein phosphatase binding
- protein binding
- transmembrane receptor protein tyrosine kinase adaptor activity
- insulin receptor binding
- 14-3-3 protein binding