Hsd17b14 Gene Summary [Rat]
Enables D-threo-aldose 1-dehydrogenase activity. Predicted to be involved in L-fucose catabolic process and steroid catabolic process. Predicted to be active in cytosol. Orthologous to human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsd17b14 |
| Official Name | hydroxysteroid (17-beta) dehydrogenase 14 [Source:RGD Symbol;Acc:1588673] |
| Ensembl ID | ENSRNOG00000020949 |
| Bio databases IDs | |
| Aliases | hydroxysteroid (17-beta) dehydrogenase 14 |
| Synonyms | 0610039E24RIK, DHRS10, hydroxysteroid (17-beta) dehydrogenase 14, hydroxysteroid 17-beta dehydrogenase 14, hydroxysteroid (17-β) dehydrogenase 14, hydroxysteroid 17-β dehydrogenase 14, retSDR3, SDR47C1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hsd17b14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- estradiol 17beta-dehydrogenase
- KR domain
- D-threo-aldose 1-dehydrogenase
- pteridine reductase
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- identical protein binding
- polyketide synthase keto reductase domain
- sepiapterin reductase
- testosterone 17beta-dehydrogenase (NADP)
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Hsd17b14 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hsd17b14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- steroid catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- estradiol 17-beta-dehydrogenase activity
- identical protein binding
- protein binding
- testosterone 17-beta-dehydrogenase (NADP+) activity