Slc22a12 Gene Summary [Rat]
Predicted to enable PDZ domain binding activity and urate transmembrane transporter activity. Involved in cellular response to insulin stimulus; renal urate salt excretion; and urate transport. Located in apical plasma membrane. Biomarker of diabetes mellitus. Orthologous to human SLC22A12 (solute carrier family 22 member 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc22a12 |
| Official Name | solute carrier family 22 member 12 [Source:RGD Symbol;Acc:621628] |
| Ensembl ID | ENSRNOG00000021108 |
| Bio databases IDs | |
| Aliases | solute carrier family 22 member 12 |
| Synonyms | AI987855, hURAT1, OAT4L, RST, SLC22AL2, solute carrier family 22 member 12, UAT, URAT1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc22a12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- benzoate transport
- Sugar (and other) transporter
- MFS transporter, sugar porter (SP) family
- Multidrug resistance protein
- Major Facilitator Superfamily
- urate transporter
- cation transport protein
- transporter
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- epilepsy
- renal hypouricemia type 1
- gout
- chronic tophaceous gout
- non-tophaceous gout
- intra-abdominal infection
- renal clear cell adenocarcinoma
- renal clear cell cancer
- familial renal hypouricemia
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc22a12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- cellular homeostasis
- ion transport
- transmembrane transport
- urate transport
- response to xenobiotic stimulus
- organic anion transport
- urate metabolic process
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- extracellular vesicular exosome
- membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- urate transmembrane transporter activity
- PDZ domain binding