Kcnk4 Gene Summary [Rat]
Enables mechanosensitive potassium channel activity; potassium ion leak channel activity; and temperature-gated cation channel activity. Involved in several processes, including cellular response to alkaline pH; cellular response to temperature stimulus; and detection of mechanical stimulus involved in sensory perception of touch. Located in node of Ranvier and plasma membrane. Orthologous to human KCNK4 (potassium two pore domain channel subfamily K member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnk4 |
| Official Name | potassium two pore domain channel subfamily K member 4 [Source:RGD Symbol;Acc:621449] |
| Ensembl ID | ENSRNOG00000021140 |
| Bio databases IDs | |
| Aliases | potassium two pore domain channel subfamily K member 4 |
| Synonyms | 1700019N12RIK, A430107B04RIK, Catsperz, FHEIG, K2p4.1, KT4.1, MLZ-622, potassium channel, subfamily K, member 4, potassium two pore domain channel subfamily K member 4, Tex40, TRAAK, TRAAK1, TRAAKt |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnk4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- outward rectifier potassium channel
- channel/pore class transporter
- protein binding
- mechanically-gated ion channel
- identical protein binding
- ion channel
- cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- facial dysmorphism, hypertrichosis, epilepsy, intellectual or developmental delay, and gingival overgrowth syndrome
regulates
- K+
role in cell
- action potential
- response by
- action potential in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- nodes of Ranvier
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnk4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- cellular response to mechanical stimulus
- potassium ion transmembrane transport
- cellular response to fatty acid
- cellular response to temperature stimulus
- cellular response to alkalinity
- sensory perception of pain
- memory
- detection of mechanical stimulus involved in sensory perception of touch
- stabilization of membrane potential
- sensory perception of temperature stimulus
Cellular Component
Where in the cell the gene product is active
- potassium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- outward rectifier potassium channel activity
- potassium channel activity
- potassium ion leak channel activity