Ndfip1 Gene Summary [Rat]
Predicted to enable WW domain binding activity. Predicted to be involved in several processes, including negative regulation of transport; positive regulation of canonical NF-kappaB signal transduction; and regulation of macromolecule metabolic process. Predicted to act upstream of or within several processes, including negative regulation of interleukin-4 production; negative regulation of type 2 immune response; and regulation of lymphocyte activation. Predicted to be located in cell cortex. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Orthologous to human NDFIP1 (Nedd4 family interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndfip1 |
| Official Name | Nedd4 family interacting protein 1 [Source:RGD Symbol;Acc:1310053] |
| Ensembl ID | ENSRNOG00000013562 |
| Bio databases IDs | |
| Aliases | Nedd4 family interacting protein 1 |
| Synonyms | 0610010M22Rik, MGC10924, N4WBP5, Nedd4 family interacting protein 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndfip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NEDD4 family-interacting protein
- WW domain binding
- protein binding
- proline tyrosine motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- Crohn disease
- ulcerative colitis
- allergy
- primary biliary cirrhosis
- allergic rhinitis
- inflammatory bowel disease
- multiple sclerosis
- anemia
- inflammatory disorder
role in cell
- quantity
- activation
- activation in
- phosphorylation in
- proliferation
- expression in
- differentiation
- binding in
- upregulation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- cell cortex
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndfip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of lymphocyte differentiation
- negative regulation of inflammatory response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of protein catabolic process
- vacuolar transport
- regulation of myeloid leukocyte differentiation
- ubiquitin-dependent protein catabolic process
- cellular iron ion homeostasis
- negative regulation of protein transport
- negative regulation of gene expression
- negative regulation of interleukin-4 production
- regulation of isotype switching to IgG isotypes
- CD4-positive, alpha-beta T cell proliferation
- negative regulation of transporter activity
- positive regulation of protein ubiquitination
- metal ion transport
- negative regulation of type 2 immune response
- negative regulation of isotype switching to IgE isotypes
- negative regulation of CD4-positive, alpha-beta T cell proliferation
Cellular Component
Where in the cell the gene product is active
- dendrite
- perinuclear region of cytoplasm
- cell cortex
- endoplasmic reticulum
- Golgi membrane
- endosome membrane
- Golgi apparatus
- synapse
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- WW domain binding