Grm8 Gene Summary [Rat]
Enables group III metabotropic glutamate receptor activity. Involved in detection of mechanical stimulus involved in sensory perception of pain; glutamatergic synaptic transmission; and modulation of chemical synaptic transmission. Located in neuronal cell body and presynaptic membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone membrane. Used to study Parkinsonism and epilepsy. Human ortholog(s) of this gene implicated in alcohol dependence; attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grm8 |
| Official Name | glutamate metabotropic receptor 8 [Source:RGD Symbol;Acc:619858] |
| Ensembl ID | ENSRNOG00000021468 |
| Bio databases IDs | |
| Aliases | glutamate metabotropic receptor 8 |
| Synonyms | A230002O04, GLUR8, glutamate metabotropic receptor 8, glutamate receptor, metabotropic 8, GPRC1H, Metabotropic glutamate receptor 8, mGlu8, mGlur, MGLUR8, mGluR8b |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Grm8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Receptor family ligand binding region
- G beta gamma protein binding domain
- Type 1 periplasmic binding fold superfamily
- Nine Cysteines Domain of family 3 GPCR
- 7 transmembrane sweet-taste receptor of 3 GCPR
- seven-transmembrane G protein-coupled receptor superfamily
- glutamate receptor
- group III metabotropic glutamate receptor
Pathways
Biological processes and signaling networks where the Grm8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- cAMP-mediated signaling
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- G-Protein Coupled Receptor Signaling
- Glutamate Receptor Signaling
- Gαi Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Synaptic Long Term Depression
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- cancer
- metabolic syndrome X
- tinnitus
- neuroticism
- idiopathic pulmonary fibrosis
- depressive disorder
- neurotic disorder
- breast cancer
- lung adenocarcinoma
regulates
- Ca2+
- phosphatidylinositol
- PKA
- neurotransmitter
- Gαi/o
- GNA15
- ADCY
role in cell
- cell viability
- fusion
- response
- oscillation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- nerve ending
- synapse
- perikaryon
- axons
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Grm8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
- G-protein coupled glutamate receptor signaling pathway
- visual perception
- regulation of synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- group III metabotropic glutamate receptor activity
- G-protein coupled receptor activity
- glutamate receptor activity