Wfikkn1 Gene Summary [Rat]
This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Wfikkn1 |
| Official Name | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 [Source:RGD Symbol;Acc:1565835] |
| Ensembl ID | ENSRNOG00000021578 |
| Bio databases IDs | |
| Aliases | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 |
| Synonyms | C16orf12, Gasp2, Oc29, RGD1565835, RJD2, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1, WAP, FS, Ig, KU, and NTR-containing protein 1, WFDC20A, WFIKKN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wfikkn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
- WAP-type (Whey Acidic Protein) 'four-disulfide core'
- receptor antagonist activity
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- KAZAL_FS
- TGFbeta binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wfikkn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- muscle cell development
- palate development
- transforming growth factor beta receptor signaling pathway
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- transforming growth factor beta binding
- serine-type endopeptidase inhibitor activity
- protein binding
- receptor antagonist activity