Sdhd Gene Summary [Rat]
Predicted to enable several functions, including heme binding activity; succinate dehydrogenase (quinone) activity; and ubiquinone binding activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone and tricarboxylic acid cycle. Predicted to act upstream of or within cellular response to hypoxia and regulation of catecholamine secretion. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHD (succinate dehydrogenase complex subunit D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sdhd |
| Official Name | succinate dehydrogenase complex subunit D [Source:RGD Symbol;Acc:735231] |
| Ensembl ID | ENSRNOG00000022980 |
| Bio databases IDs | |
| Aliases | succinate dehydrogenase complex subunit D |
| Synonyms | 3110001M13RIK, AVLL5809, C78570, CBT1, CII-4, CWS3, cybS, MC2DN3, PGL, PGL1, PPGL1, PRO19626, QPs3, SDH4, SDHD1, succinate dehydrogenase complex subunit D, succinate dehydrogenase complex, subunit D, integral membrane protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sdhd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- electron carrier
- CybS, succinate dehydrogenase cytochrome B small subunit
- SQR_QFR_TM
- ubiquinone binding
- protein binding activity, bridging
- enzyme
- protein binding
- heme binding
- succinate dehydrogenase (ubiquinone)
Pathways
Biological processes and signaling networks where the Sdhd gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- paraganglioma type 3
- ACTH producing cell hyperplasia
- C cell hyperplasia
- paraganglioma type 1
- pheochromocytoma
- pheochromocytoma formation
- organismal death
- hereditary cancer-predisposing syndrome
- abdominal paraganglioma formation
- paraganglioma formation
regulates
- HIF1A
- adenosine triphosphate
- succinic acid
- 5-methylcytosine
- SDH
- Hif1
- fumaric acid
- 5-hydroxymethylcytosine
role in cell
- apoptosis
- activation in
- growth
- function
- invasiveness
- enlargement
- response by
- glycolysis in
- enlargement in
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial envelope
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sdhd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of catecholamine secretion
- mitochondrial electron transport, succinate to ubiquinone
- tricarboxylic acid cycle
- cellular response to hypoxia
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex II
- mitochondrion
- mitochondrial envelope
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- succinate dehydrogenase (ubiquinone) activity
- metal ion binding
- electron carrier activity
- ubiquinone binding
- heme binding