Nlrp5 Gene Summary [Rat]
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Nlrp5 |
| Official Name | NLR family, pyrin domain containing 5 [Source:RGD Symbol;Acc:1307446] |
| Ensembl ID | ENSRNOG00000022994 |
| Bio databases IDs | |
| Aliases | NLR family, pyrin domain containing 5 |
| Synonyms | CLR19.8, MATER, NALP5, NLR family pyrin domain containing 5, NLR family, pyrin domain containing 5, Op1, OZEMA19, PAN11, PYPAF8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nlrp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- Repeat of unknown function (DUF1103)
- PAAD/DAPIN/Pyrin domain
- NOD2 winged helix domain
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- protein binding
- NACHT domain
- tubulin binding
- Leucine rich repeat, ribonuclease inhibitor type
- structural molecule
- Death Domain Superfamily of protein-protein interaction domains
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Nlrp5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune oophoritis
- oocyte/zygote/embryo maturation arrest 19
- oocyte maturation defect
- polycystic ovary syndrome
regulates
- protein-protein complex
- Immunoglobulin
role in cell
- fertilization
- exocytosis by
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- organelle
- cell cortex
- Nucleus
- Golgi Apparatus
- Mitochondria
- cytosol
- nucleoli
- cortical granules
- apical cortex
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nlrp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell division
- regulation of localization
- cortical granule exocytosis
- establishment of spindle localization
- actin filament organization
- regulation of inflammatory response
- positive regulation of embryonic development
- exocytosis
- establishment of organelle localization
Cellular Component
Where in the cell the gene product is active
- cortical granule
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cell cortex
- mitochondrion
- cytosol
- Golgi apparatus
- nucleolus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- tubulin binding
- protein binding