Support
icon_0328_cc_gen_hmr_bacteria-s

Role of PKR in Interferon Induction and Antiviral Response

Protein kinase receptor (PKR) belongs to a family of pattern-recognition receptors (PRRs). It can be induced by interferons (IFNs) as well as dsRNA from viral sources. It is a cytoplasmic kinase that responds to viral and IFN triggers mainly by apoptosis of the host cell or by inhibition of translation, affecting both viral and cellular mRNA. Protein synthesis is inhibited by phosphorylating the translation initiation factor eIF2alpha. Apoptosis can be activated via death receptor pathways involving FADD and the caspases, as well as by direct phosphorylation of p53...

Role of PKR in Interferon Induction and Antiviral Response

Pathway Summary

Protein kinase receptor (PKR) belongs to a family of pattern-recognition receptors (PRRs). It can be induced by interferons (IFNs) as well as dsRNA from viral sources. It is a cytoplasmic kinase that responds to viral and IFN triggers mainly by apoptosis of the host cell or by inhibition of translation, affecting both viral and cellular mRNA. Protein synthesis is inhibited by phosphorylating the translation initiation factor eIF2alpha. Apoptosis can be activated via death receptor pathways involving FADD and the caspases, as well as by direct phosphorylation of p53. Much of PKR signal transduction, however, occurs via NF-κB and MAPK pathways, which trigger various antiviral effects especially the production of type I IFNs and increased expression of pro-apoptotic factors. (Upgraded 01/2020)

Role of PKR in Interferon Induction and Antiviral Response Genes list

Explore Genes related to Role of PKR in Interferon Induction and Antiviral Response

Products related to Role of PKR in Interferon Induction and Antiviral Response

Explore products related to Role of PKR in Interferon Induction and Antiviral Response
GeneGlobe ID: SBHS-016Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Type I Interferon Response
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-064Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Interferons & Receptors
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-064Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Interferons & Receptors
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-016Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Type I Interferon Response
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: PAHS-016Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Type I Interferon Response
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-064Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Interferons & Receptors
RT2 Profiler PCR Array
Product Specification
Copy Details

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.