Pard3b Gene Summary [Rat]
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including establishment of cell polarity; establishment of centrosome localization; and establishment or maintenance of epithelial cell apical/basal polarity. Predicted to be located in cell junction. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Orthologous to human PARD3B (par-3 family cell polarity regulator beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pard3b |
| Official Name | par-3 family cell polarity regulator beta [Source:RGD Symbol;Acc:1584992] |
| Ensembl ID | ENSRNOG00000024345 |
| Bio databases IDs | |
| Aliases | par-3 family cell polarity regulator beta |
| Synonyms | 1810008K04RIK, 2010002N16Rik, 2810455B10Rik, ALS2CR19, LOC105373846, PAR3B, PAR3beta, par-3 family cell polarity regulator beta, par-3 family cell polarity regulator β, PAR3L |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pard3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
- N-terminal of Par3 and HAL proteins
- cpPDZ_RseP_YlbL-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- open-angle glaucoma
- attention deficit hyperactivity disorder
- Goldenhar syndrome
- cerebral aneurysm
- osteoarthritis
- autism
- acute myeloid leukemia
- schizophrenia
- hypertrophic cardiomyopathy
regulates
role in cell
- formation
- activation in
- inhibition in
- inhibition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- Cytoplasm
- cellular membrane
- cell-cell contacts
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pard3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- establishment of centrosome localization
- establishment or maintenance of epithelial cell apical/basal polarity
- protein localization
- establishment of cell polarity
- cell adhesion
- microtubule cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- adherens junction
- tight junction
- cell cortex
- apical junction complex
- cell junction
- endomembrane system
- macromolecular complex
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol binding